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KMID : 0438520110180010049
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Journal of the Korean Society of Neonatology
2011 Volume.18 No. 1 p.49 ~ p.58
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Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth
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Sohn Jin-A
Park Eun-Ae
Cho Su-Jin
Kim Young-Ju
Park Hye-Sook
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Abstract
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Purpose: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM).
Methods: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data.
Results: Cord adiponectin was lower in the GDM group than in the non-GDM group ( P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group ( P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group ( P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different ( P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity.
Conclusion: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.
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KEYWORD
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Adiponectin, Insulin-like growth factor-I, Cord blood, Gestational diabetes mellitus
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